11 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ISG15 counteracts Listeria monocytogenes infection

    Lilliana Radoshevich et al.
    The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.
    1. Cancer Biology

    LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

    Pang-Kuo Lo et al.
    LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IRF4 haploinsufficiency in a family with Whipple’s disease

    Antoine Guérin et al.
    Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.
    1. Microbiology and Infectious Disease

    Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

    Edward JD Greenwood et al.
    A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Trisomy 21 consistently activates the interferon response

    Kelly D Sullivan et al.
    Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
    1. Biochemistry and Chemical Biology

    SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

    Kate E Coleman et al.
    Aberrant neddylation of non-cullin substrates disrupts normal cell cycle progression.
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang et al.
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim et al.
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

    Jonas Klinkhammer et al.
    Interferon-λ plays a decisive and previously underestimated role in limiting the spread of respiratory viruses from the nasal cavity to the lungs and it efficiently restricts virus transmission from infected individuals to naïve contacts.
    1. Cell Biology

    TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

    Katerina Leonova et al.
    Type I interferon signaling protects cells from the loss of epigenetic integrity, since it is activated in cells in response to accumulation of transcripts originating from normally silenced heterochromatin, caused by small-molecule-mediated nucleosome unfolding.

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