5,541 results found
    1. Neuroscience

    Sexually dimorphic neuronal responses to social isolation

    Laura Senst, Dinara Baimoukhametova ... Jaideep Singh Bains
    Male and female mice react differently to social isolation but not to an acute physical stress.
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong, Keisuke Ejima ... Marco Ajelli
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Genetics and Genomics
    2. Neuroscience

    Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

    Ryoji Amamoto, Mauricio D Garcia ... Constance L Cepko
    Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.
    1. Cancer Biology

    Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

    Yogev Sela, Jinyang Li ... Ben Z Stanger
    A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
    1. Neuroscience

    Oxytocin neurons mediate the effect of social isolation via the VTA circuits

    Stefano Musardo, Alessandro Contestabile ... Camilla Bellone
    Oxytocin neurons in the paraventricular nucleus of the hypothalamus mediate the increased sociability as a consequence of acute social isolation during adolescence via ventral tegmental area circuits.
    1. Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala, Gaurav Swarnkar ... Yousef Abu-Amer
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.
    1. Epidemiology and Global Health
    2. Neuroscience

    Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study

    Laurenz Lammer, Frauke Beyer ... A Veronica Witte
    Analyses of longitudinal neuroimaging data highlight the importance of social contact for brain health.
    1. Neuroscience

    Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

    Derya Sargin, David K Oliver, Evelyn K Lambe
    Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Framework for rapid comparison of extracellular vesicle isolation methods

    Dmitry Ter-Ovanesyan, Maia Norman ... David R Walt
    Measuring surface proteins on extracellular vesicles enables quantitative comparison of different isolation methods and optimization of size exclusion chromatography.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ISG15 counteracts Listeria monocytogenes infection

    Lilliana Radoshevich, Francis Impens ... Pascale Cossart
    The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.

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