RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
Analysis of conformational heterogeneity in cryo-EM data by a recently developed deep learning method reveals the structure and dynamics of the oncogenic chromatin remodeler ALC1 bound to a poly-ADP-ribosylated nucleosome.
Identifying the pathways that support human naive-state pluripotent stem cells provides insights into the signalling-based regulation of human pluripotency and enables informed decisions to improve conditions for pluripotent cell culture.
Pre-migratory and early migratory neural crest cells in zebrafish are transcriptionally diverse, with some cells expressing genes associated with differentiated derivatives while still in the neural tube.
Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.