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    1. Computational and Systems Biology
    2. Ecology

    Nomadic-colonial life strategies enable paradoxical survival and growth despite habitat destruction

    Zhi Xuan Tan, Kang Hao Cheong
    By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
    1. Cell Biology
    2. Computational and Systems Biology

    Evaluation of predictions of the stochastic model of organelle production based on exact distributions

    C Jeremy Craven
    A reanalysis of the stochastic model of organelle production (Mukherji and O'Shea, 2014) suggests that this model requires significant further discussion.
    1. Neuroscience

    Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

    James B Isbister, András Ecker ... Michael W Reimann
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau, Nicolas Larmonier ... Andreas Bikfalvi
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
    1. Epidemiology and Global Health

    Science Forum: Unit of analysis issues in laboratory-based research

    Nick R Parsons, M Dawn Teare, Alice J Sitch
    A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.
  1. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.
    1. Medicine

    Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
    1. Plant Biology

    Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

    Maryam Rahmati Ishka, Hayley Sussman ... Magdalena M Julkowska
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Transdiagnostic compulsivity is associated with reduced reminder setting, only partially attributable to overconfidence

    Annika Boldt, Celine A Fox ... Sam Gilbert
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing