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Developmental genetic and cell culture studies indicate that the Inhibitor of DNA-binding protein Extra macrochaetae (Emc), previously thought to determine where bHLH proteins can act, is itself regulated by those bHLH dimerization partners at the level of protein stability.

Dorsomedial D2-MSNs and D1-MSNs exhibit opposing dynamics during interval timing, however disrupting either MSN type produces similar effects on behavior, highlighting the complementary roles of striatal pathways in cognitive operations.

Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.

Increasing adult-born neurons in the dentate gyrus reduces neuronal loss and chronic seizures in female mice using a mouse model of temporal lobe epilepsy.

Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.

Biochemical reconstitution experiments uncover the ubiquitin-mediated function of a DNA repair protein, key to the understanding of Fanconi Anemia, a cancer-associated bone marrow failure syndrome.

Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.

Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.

A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.

Machine learning identified six protective antibody features and showed for the first time that serological markers can predict protection from placental-malaria, which is important for evaluation and development of vaccines.