Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.

The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.

An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.

Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.