1,015 results found
    1. Immunology and Inflammation

    The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

    Zhengpeng Wan et al.
    The B cell receptors of naïve B cells need higher levels of mechanical force to be fully activated than those of memory B cells.
    1. Immunology and Inflammation

    TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

    Hannah P Savage et al.
    B-1 cell unresponsiveness to antigen-stimulation is overcome during infections when Toll-like receptor engagement removes negative regulators of B cell receptor signaling, thereby supporting B-1 cell differentiation to IgM-secreting plasmablasts.
    1. Immunology and Inflammation

    Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

    Zhixun Shen et al.
    Conformational changes occur within extracellular domain of BCR upon antigen engagement, and these conformational changes are related with the strength of BCR activation and are distinct in IgM- and IgG-BCR.
    1. Ecology

    Mass Spawning: Sex under the moon

    Didier Zoccola, Sylvie Tambutté
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Neuroscience

    NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei-Fang Xiao et al.
    Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.
    1. Neuroscience

    Bmal1 function in skeletal muscle regulates sleep

    J Christopher Ehlen et al.
    Expression of transcription factor BMAL1 in skeletal muscle reduces the recovery response to sleep loss and is both necessary and sufficient to regulate total sleep amount.
    1. Biochemistry and Chemical Biology

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.

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