647 results found
  1. Male baboon looking into the distance

    Episode 75: July 2021

    In this episode, we hear about the cost of high status, vaccine trackers, pain relief in newborns, Alzheimer's disease and how losing a partner can increase the risk of cancer.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Biochemistry and Chemical Biology

    Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

    Deepti Karandur et al.
    Activation and autophosphorylation of CaMKII releases the regulatory segment, which can then bind to and destabilize the hub assembly by trapping large fluctuations in the hub architecture.
    1. Immunology and Inflammation

    TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

    F Tudor Ilca et al.
    Immunopeptidomics in combination with novel cell-based assays that assess peptide exchange reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide dissociation and peptide selection on MHC I.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin et al.
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Developmental Biology
    2. Evolutionary Biology

    Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita

    Karl R Wotton et al.
    Quantitative system-level analysis of a pattern-forming gene regulatory network in a non-model organism shows that dynamic changes in gene expression evolve through quantitative system drift.
    1. Immunology and Inflammation

    Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

    Ghada Alsaleh et al.
    Declining TFEB and autophagy levels with age are key to poor vaccination efficacy in the elderly.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Neuroscience

    Sparse activity of identified dentate granule cells during spatial exploration

    Maria Diamantaki et al.
    Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.

Refine your results by:

Type
Research categories