21 results found
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Medicine

    Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

    Paul J Brighton et al.
    While acute senescence of decidualizing cells drives the inflammatory response underpinning uterine receptivity, subsequent clearance by activated natural killer cells transiently rejuvenates the cycling endometrium, enabling transition into a gestational tissue upon embryo implantation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Recurrent turnover of senescent cells during regeneration of a complex structure

    Maximina H Yun et al.
    Senescent cells are recurrently induced during limb regeneration in salamanders and subsequently eliminated by a highly efficient mechanism of macrophage-dependent surveillance.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.
    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
    1. Microbiology and Infectious Disease

    MARCH8 inhibits viral infection by two different mechanisms

    Yanzhao Zhang et al.
    The host transmembrane protein MARCH8, previously known as an expression regulator of host proteins, is a powerful antiviral host factor with a potentially broad antiviral spectrum through two different mechanisms.
    1. Developmental Biology
    2. Immunology and Inflammation

    Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice

    Ying Wang et al.
    A distinct resident macrophage subpopulation that localizes to the adipose stroma and fibrous capsule of the nulliparous mammary gland and to extracellular matrix-enriched stroma surrounding mammary tumors is identified.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

    Lina Sagert et al.
    A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.

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