3,428 results found
    1. Cell Biology
    2. Developmental Biology

    Optogenetic investigation of BMP target gene expression diversity

    Katherine W Rogers et al.
    Optogenetic manipulation of BMP signaling indicates that diversity in BMP-dependent gene expression is not well explained by differential responses to BMP, and combinatorial signaling is a major driver of diversity.
    1. Developmental Biology

    Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1

    Antonio Galeone et al.
    N-glycanase 1 is required for a BMP autoregulatory loop in the visceral mesoderm and for intestinal development in Drosophila.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke et al.
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems biology derived source-sink mechanism of BMP gradient formation

    Joseph Zinski et al.
    Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
    1. Immunology and Inflammation

    The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB

    Dominik Schmiedel et al.
    The well-established oncogene IMP3 impairs the interaction between cancer cells and the immune system.
    1. Developmental Biology

    SMOC can act as both an antagonist and an expander of BMP signaling

    J Terrig Thomas et al.
    SMOC inhibits BMP signaling locally, but also expands the range of BMP signaling by competing for heparan sulfate binding sites.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Microbiology and Infectious Disease

    c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility

    Bridget R Kulasekara et al.
    Real time measurements of c-di-GMP in individual cells reveal an unexpected mechanism by which the chemotaxis machinery controls c-di-GMP heterogeneity, thereby regulating flagellar-based motility.
    1. Developmental Biology

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström et al.
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Developmental Biology
    2. Neuroscience

    MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons

    Caitlin Engelhard et al.
    A protein called Megf8 regulates the activity of key signaling molecules involved in the development of the peripheral nervous system.

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