Enterovirus D68, a pathogen associated with a rare child paralysis disease, depends on the cellular protein SIRT-1 for release of virus, indicating that SIRT-1 may be an important therapeutic target.
Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
Building on previous work (Reznik et al., 2016), independent measurements of mitochondrial genome copy number and expression indicate that several solid tumor types suppress respiratory metabolism compared to normal tissue.
Rajdeep Banerjee, Thomas J Meyer ... David D Roberts
Increased extramedullary erythropoiesis in spleen compensates for the elevated turnover of red blood cells in mice lacking CD47, but extramedullary erythropoiesis is suppressed in mice lacking the CD47 ligand thrombospondin-1.
Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.
