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    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

    Meaghan Castledine, Daniel Padfield ... Angus Buckling
    Parallel evolutionary dynamics were found in vivo and in vitro, showing that laboratory studies can be predictive of certain phenotypic outcomes of clinical phage therapy (phage-mediated decolonization).
    1. Neuroscience

    Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

    Rohan Gala, Daniel Lebrecht ... Armen Stepanyants
    BoutonAnalyzer software makes it possible to detect axonal boutons and measure their structural plasticity in long-term in vivo imaging experiments.
    1. Neuroscience

    Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation

    Yu Huang, Anli A Liu ... Lucas C Parra
    Direct in-vivo measurements in the human brain test validity of detailed computational models of trancranial electric stimulation and show that electric fields in the brain are weaker than currently assumed.
    1. Physics of Living Systems

    The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid

    Celine Bellegarda, Guillaume Zavard ... Claire Wyart
    Experimental manipulations and a mechanical model of the fiber reveal that the Reissner fiber is under heterogenous tension in vivo, and interacts with the motile cilia of diverse cells contacting the cerebrospinal fluid.
    1. Neuroscience

    Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo

    Jin Bao, Michael Graupner ... Isabel Llano
    During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.
    1. Developmental Biology

    High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila

    Jun-yi Zhu, Yulong Fu ... Zhe Han
    A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.
    1. Neuroscience

    Multi-neuron intracellular recording in vivo via interacting autopatching robots

    Suhasa B Kodandaramaiah, Francisco J Flores ... Craig R Forest
    A robot capable of automatically obtaining blind whole cell patch clamp recordings from multiple neurons simultaneously guides four interacting electrodes in a coordinated fashion, avoiding mechanical coupling in the brain.
    1. Biochemistry and Chemical Biology

    Measurement of average decoding rates of the 61 sense codons in vivo

    Justin Gardin, Rukhsana Yeasmin ... Bruce Futcher
    The translation rates of each yeast codon have been measured in both the A and P sites of the ribosome.
    1. Microbiology and Infectious Disease

    Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

    Lisanne de Vor, Bruce van Dijk ... Suzan HM Rooijakkers
    Antibody-based biologicals could provide an alternative approach to improve the diagnosis of Staphylococcus aureus biofilm-related infections.