1,614 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera et al.
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

    Michele Felletti et al.
    Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
    1. Microbiology and Infectious Disease

    Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

    Philip V'kovski et al.
    The molecular microenvironment of coronaviral replicase complexes provides functional and spatial links between conserved cellular processes and viral RNA synthesis, and highlights potential targets for the development of novel antivirals.
    1. Microbiology and Infectious Disease

    pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

    Kenji Sugiyama et al.
    The host-derived factors, pp32 and APRIL, interact with influenza viral RNA polymerase to support viral genomic RNA synthesis from complementary RNA.
    1. Biochemistry and Chemical Biology

    A novel DNA primase-helicase pair encoded by SCCmec elements

    Aleksandra Bebel et al.
    SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.
    1. Chromosomes and Gene Expression

    The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription

    Eva Torreira et al.
    Live-cell imaging, genetic analysis and electron cryomicroscopy identify structural motifs involved in the differential assembly of Pol I-Rrn3 complexes and Pol I homodimers in response to nutrient availability.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Chromosomes and Gene Expression

    The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

    Jyothsna Visweswaraiah et al.
    A structural element of mRNA exit channel protein Rps5 performs a critical role in start codon recognition during translation initiation by stabilizing initiator tRNA binding to the pre-initiation complex.
    1. Chromosomes and Gene Expression

    Kinetic competition during the transcription cycle results in stochastic RNA processing

    Antoine Coulon et al.
    Real-time single-molecule visualization of transcription and splicing in living cells reveals that RNA synthesis and processing can occur through multiple pathways on the same gene.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

    James Chen et al.
    Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.

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