920 results found
    1. Cell Biology
    2. Genetics and Genomics

    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

    Malini Rajan et al.
    Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..
    1. Immunology and Inflammation

    MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

    Hui Xu et al.
    The liver-specific miRNA microRNA-122 plays a previously unknown role in hepatocyte intrinsic innate immunity by targeting the RTKs/STAT3 signaling pathway.
    1. Cell Biology
    2. Plant Biology

    Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity

    Amutha Sampath Kumar et al.
    Stromules induced during plant innate immunity dynamically interact and use the cytoskeleton to form and to direct the movement of chloroplasts.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

    Harriet Lane-Serff et al.
    The structure of the trypanosome haptoglobin-haemoglobin receptor bound to its ligand reveals the molecular basis for ligand recognition in innate immunity and identifies molecular determinants that aid efficient uptake.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

    Brian J Ferguson et al.
    Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.
    1. Plant Biology

    The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth

    Rosa Lozano-Durán et al.
    The transcriptional regulator BZR1 acts as a molecular integrator of environmental cues regulating the trade-off between growth and innate immunity.
    1. Cancer Biology
    2. Cell Biology

    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

    Chiho Kim et al.
    Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

    Alison C McKelvey et al.
    Novel post-translational modification of pattern recognition receptor TLR2 has consequences in bacterial infection and inflammatory signaling.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

    Lukasz Kedzierski et al.
    The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

    Katherine A Smith et al.
    Immune expulsion of helminth parasites is driven by two key pathways mediated by soluble cytokines ligating to the IL-4 and IL-25 receptors acting on innate effector cells throughout the course of infection.

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