444 results found
    1. Chromosomes and Gene Expression

    Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

    Oliver Willhoft et al.
    Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.
    1. Chromosomes and Gene Expression

    Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

    Jiying Sun et al.
    ATM plays an important role in maintaining the fidelity of DNA repair through the regulation of ARP8 phosphorylation to prevent the chromosome abnormality.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h

    Nathan Gamarra et al.
    Auto-inhibition of ISWI-family ATP-dependent chromatin remodelers is relieved by a conserved feature of the nucleosome.
  1. Research: Publication bias and the canonization of false facts

    Silas Boye Nissen et al.
    Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
  2. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Chromatin: Assembly, remodelled

    Karim Bouazoune, Robert E Kingston
    Insight
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    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson et al.
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Ecology
    2. Evolutionary Biology

    Point of View: Towards a mechanistic foundation of evolutionary theory

    Michael Doebeli et al.
    A description of evolution that is based on birth-death processes, and in which fitness is at most a derived quantity, is advocated.
    1. Physics of Living Systems

    Point of View: Are theoretical results ‘Results’?

    Raymond E Goldstein
    There should be a prominent place for theory within biology papers, both as Results in papers that combine experiment and theory, and as Results in theory papers.

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