935 results found
    1. Chromosomes and Gene Expression

    Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

    Oliver Willhoft, Elizabeth A McCormack ... Dale B Wigley
    Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.
    1. Cell Biology
    2. Developmental Biology

    Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma

    Tsuyoshi Morita, Ken'ichiro Hayashi
    Actin-related protein 5 antagonizes the interaction of Pbx/Meis with myogenic regulatory factors such as MyoD and MyoG, which is involved in the recruitment of the BRG1-based switch/sucrose nonfermentable chromatin remodeling complex required for myogenic gene activation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex

    Michael Tramantano, Lu Sun ... Ed Luk
    The transcription machinery is required for the disassembly of the promoter-proximal H2A.Z nucleosome, contributing to the constitutive histone turnover at yeast promoters.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander, Björn C Willige ... Joseph R Ecker
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Chromosomes and Gene Expression

    Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

    Jiying Sun, Lin Shi ... Satoshi Tashiro
    ATM plays an important role in maintaining the fidelity of DNA repair through the regulation of ARP8 phosphorylation to prevent the chromosome abnormality.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h

    Nathan Gamarra, Stephanie L Johnson ... Geeta J Narlikar
    Auto-inhibition of ISWI-family ATP-dependent chromatin remodelers is relieved by a conserved feature of the nucleosome.
    1. Chromosomes and Gene Expression

    Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

    Xuan Li, Jessica K Tyler
    The human genome is unpackaged to allow DNA breaks to be joined back together, and then repackaged into chromosomes afterwards.
    1. Chromosomes and Gene Expression

    Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

    Jee Min Kim, Pat Visanpattanasin ... Carl Wu
    Chromatin remodeling enzymes perform target search by utilizing ATP-binding and hydrolysis to facilitate 1D-diffusion on and rapid detachment from chromatin in living yeast.
    1. Chromosomes and Gene Expression

    Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

    Anand Ranjan, Vu Q Nguyen ... Carl Wu
    Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

    Aixin Song, Zachary Hazlett ... Tingting Yao
    Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.

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