264 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck et al.
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Neuroscience

    Cell-specific synaptic plasticity induced by network oscillations

    Shota Zarnadze et al.
    Recordings of cellular and network activities of the mouse brain provide insights into how gamma rhythms contribute to memory formation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Point of View: Tuberculosis innovations mean little if they cannot save lives

    Madhukar Pai, Jennifer Furin
    Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
    1. Neuroscience

    Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille et al.
    In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet et al.
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells et al.
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.
    1. Cell Biology
    2. Developmental Biology

    Macrophages are necessary for epimorphic regeneration in African spiny mice

    Jennifer Simkin et al.
    Inflammatory cells differentially regulate a scarring versus a regenerating response to injury in mammals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.
    1. Cancer Biology

    TP53 drives invasion through expression of its Δ133p53β variant

    Gilles Gadea et al.
    Clinical analysis corroborated with experimental data demonstrate that Δ133p53β, a naturally occurring isoform of p53 protein, induces a pro-metastatic program and is a clinical indicator of metastasis, independently of TP53 mutation status.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.

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