192 results found
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Medicine
    2. Neuroscience

    The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

    Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt
    Transcutaneous auricular vagus nerve stimulation is a safe neuromodulatory treatment for subarachnoid hemorrhage patients, with potential benefits for restoring autonomic balance.
    1. Immunology and Inflammation

    Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

    Mengyun Li, Huan Jin ... Xiaojun Xia
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

    Mie Suzuki-Okutani, Shinya Okamura ... Hirotaka Ebina
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation
    2. Medicine

    JAK inhibition decreases the autoimmune burden in Down syndrome

    Angela L Rachubinski, Elizabeth Wallace ... Joaquín M Espinosa
    Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Cell Biology
    2. Medicine

    Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice

    Shuo He, Lei Huang ... Jinlong He
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Inadequate
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