Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.

The MADA motif is functionally conserved across NLRs from distantly related plants and has degenerated in sensor NLRs over evolutionary time.

Collaborative transcription factors (TFs) exhibit a dominant pattern of a relaxed range of spacing and substantial tolerance of spacing alterations resulting from naturally occurring insertions and deletions in comparison to genetic variants directly affecting TF binding sites.

A decline in iron-recycling functions of the splenic red pulp macrophages early during aging is driven by iron loading and involves their damage and a loss in red blood cell clearance capacity.

Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.

Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.

The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.