The Interleukin 1 beta signaling and tissue inflammation act as a double-edged sword: they are required for regeneration, but when in excess, they impair tissue regeneration and induce apoptosis.

Excessive inflammation of the brain in early life predisposes individuals to neurodevelopmental disorders by preventing synapses from developing correctly.

Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.

Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.

c-Maf is a novel key regulator of the type 3-to-1 conversion of CCR6^– ILC3s that controls the functional plasticity of ILC3s by acting as a cell-intrinsic gatekeeper of T-bet expression.

The results presented here indicate that IL-10-producing CD4⁺ T cells express genes associated with chronically activated T_H1-like cells, undergo clonal expansion, and inhibit antiviral T cell responses via the secretion of arginase-1, facilitating viral persistence in mice infected with MCMV.

Vitamin A formation from β-carotene promotes an anti-inflammatory environment and remodeling of atherosclerotic lesions during the healing of atherosclerosis.

Preclinical multilaboratory studies are a robust method to assess promising interventions.

Lutheran is a novel marker for classification of bile duct remodeling in distinct liver injury, and an interesting functional molecule for investigating the nature of liver stem/progenitor cells during regeneration.

Molecular genetics identifies a novel microglial pathway essential for mouse brain development and a previously unknown anti-inflammatory activity of monomeric amyloid β that activates this pathway.