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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    Zhiwang Zhang, Qichao Liao ... Lei Zhou
    Gene function studies confirmed that the BATF-PD1 axis and BATF-IL27 axis are regulatory factor for lipid accumulation in hepatocytes and adipocytes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp, James DeGregori ... Frédéric Thomas
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna, Fabrice Uhel ... Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Immunology and Inflammation

    The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide

    Bing Li, Prasanna Suresh ... David Klenerman
    Amyloid-beta aggregates and lipopolysaccharide differ in their kinetics of Myddosome formation and size of Myddosome formed, providing an explanation for the less efficient triggering of TLR4 observed with aggregates.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

    Kathrin Tomasek, Alexander Leithner ... Michael Sixt
    By binding with their type 1 pili to the cell surface receptor CD14, pathogenic E. coli suppress the capacity of dendritic cells to activate T cells.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

    Giulia Leanza, Malak Faraj ... Nicola Napoli
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Medicine

    Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor

    Li Chen, Zhenzhen Song ... Guoying Zhang
    IL-33 plays an important role in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.
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