229 results found
    1. Immunology and Inflammation

    Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

    Naresh S Redhu et al.
    A detailed time-series analysis reveals that the interleukin-10 receptor prevents susceptibility to microbiota-driven colonic inflammation that emerges at the time of weaning by directly inhibiting the acquisition of a pro-inflammatory intestinal macrophage phenotype.
    1. Neuroscience

    Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

    Romana Tomasoni et al.
    Excessive inflammation of the brain in early life predisposes individuals to neurodevelopmental disorders by preventing synapses from developing correctly.
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Immunology and Inflammation
    2. Medicine

    Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2

    Kelsey E Huntington et al.
    A mutual information algorithm points to macrophage activation syndrome as a specific pathogenic mechanism in COVID-19, correlated with disease severity, which could be used to monitor disease and therapeutics.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Developmental Biology

    Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

    Ines Lahmann et al.
    Met and Cxcr4 signaling protects muscle stem cells from the noxious environment during acute inflammation.
    1. Immunology and Inflammation
    2. Medicine

    An open label trial of anakinra to prevent respiratory failure in COVID-19

    Evdoxia Kyriazopoulou et al.
    Early suPAR-guided anakinra decreases the risk for severe respiratory failure in SARS-CoV-2 pneumonia and restores the pro-/anti-inflammatory balance.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

    Caleb R Glassman et al.
    A panel of interleukin-2 partial agonists designed to exploit distinct immune cell response thresholds enabled selective activation of regulatory T cells in vivo.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration

    Heather S Loring et al.
    The catalytic activity of SARM1, a key promoter of neuronal degeneration, is activated by >2000-fold by a phase transition.

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