3,782 results found
    1. Biochemistry and Chemical Biology

    Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

    Nadinath B Nillegoda et al.
    The emergence of complementary electrostatic potentials after the prokaryotic-to-eukaryotic split drives physical and functional cooperation between canonical class A and class B J-proteins to boost protein disaggregation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

    Steffen Preissler et al.
    AMPylation of BiP allosterically interferes with stimulation of its ATPase activity by J-proteins that is required for high affinity substrate binding.

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