1,536 results found
    1. Developmental Biology
    2. Neuroscience

    Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification

    Jing Zhao et al.
    During neurogenesis, Neurogenin 1 activates the microRNA miR-9, which directly targets the Jak-Stat pathway to inhibit astrogliogenesis.
    1. Stem Cells and Regenerative Medicine

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Developmental Biology

    Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

    Hervé Alégot et al.
    A morphogen gradient can trigger tissue elongation via a control of apical cell pulsing and without a planar cell polarity requirement.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

    Wael Bazzi et al.
    Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila.​.
    1. Developmental Biology
    2. Human Biology and Medicine

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu et al.
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Immunology and Inflammation

    Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

    Naren Srinivasan et al.
    Extracellular actin is an evolutionarily-conserved signal of tissue injury that is recognised in the fruit fly via similar machinery as reported in vertebrates.
    1. Developmental Biology
    2. Immunology and Inflammation

    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

    Katrin Kierdorf et al.
    A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.
    1. Immunology and Inflammation

    α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

    Oliver Gordon et al.
    The Drosophila response to injection of alpha-actinin reinforces the notion that exposure of cytoskeletal components acts as a sign of cell damage conserved throughout metazoan evolution.
    1. Cell Biology
    2. Developmental Biology

    Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

    Cuie Chen et al.
    A separation-of-function mutation reveals that a niche ligand receptor Dome functions in spindle orientation during asymmetric stem cell division by directly binding to Eb1, independent of its role in downstream JAK-STAT signaling.
    1. Cell Biology

    Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

    Yi Xiong et al.
    Genetic mouse models show that hepatic NIK and IKKα inhibit hepatocyte proliferation and liver regeneration in part by inhibiting the JAK2/STAT3 pathway.

Refine your results by:

Type
Research categories