Integrons deploy a variety of adaptive strategies including excision, shuffling, and duplication of cassettes that foster rapid bacterial adaptation and resistance evolution while protecting the genomic integrity of the host.
A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
Dietary selenium supplementation confers to mice all of the short-term healthspan benefits of the longevity-promoting intervention methionine restriction, and thus may represent a method to promote healthy aging in mammals.
Pre-complexation of vinculin with talin’s R8 domain facilitates nascent adhesion maturation by unfolding talin, increasing vinculin binding, and thereby transmitting traction forces to the environment.
Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
Analysis of conformational changes indicates that activation of acid-sensing ion channels involves protonation of diverse extracellular sites and interaction of interdomain loops with the upper ends of transmembrane helices.