1,328 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Discovery and Translation of Cancer Immunology: A Special Issue

    Edited by Jeffrey Settleman et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of the immune response to cancer cells.
  1. Ion channels: A Collection of Articles

    Edited by Kenton J Swartz et al.
    eLife has published papers on topics related to the molecular structure and functional mechanisms of a diverse array of ion channel proteins.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

    Alisa Atkins et al.
    The structural maintenance of chromosomes complex, SMC5/6, is crucial for brain development and function as it ensures proficient DNA replication in neural progenitor cells prior to chromosome segregation.
    1. Immunology and Inflammation

    Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

    Matthew D Lauver et al.
    Cryo EM and a custom subvolume refinement approach applied to mouse polyomavirus revealed the in vivo impact of polyomavirus capsid mutations on antiviral antibody immunoevasion and neurovirulence.
    1. Epidemiology and Global Health

    Time-to-event modeling of hypertension reveals the nonexistence of true controls

    Daniel Shriner et al.
    Despite health disparities among groups, the lifetime risk of hypertension approaches 100% for African Americans, European Americans, and Mexican Americans.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

    Kacy L Gordon et al.
    A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.

Refine your results by:

Type
Research categories