292 results found
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Cell Biology
    2. Neuroscience

    Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines

    Pranesh Padmanabhan et al.
    Super-resolution imaging reveals that the microtubule-associated protein Tau regulates the Fyn kinase organisation in dendrites, and that the frontotemporal dementia mutant Tau promotes aberrant Fyn clustering, potentially leading to synaptic dysfunction.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

    J Robert Lane et al.
    The occupation of a sub-pocket near the Na+-binding site in D2R by the Na+-insensitive antagonists is the structural basis for their greater inverse agonism than that of the Na+-sensitive ligands.
    1. Structural Biology and Molecular Biophysics

    New tools for automated high-resolution cryo-EM structure determination in RELION-3

    Jasenko Zivanov et al.
    RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Developmental Biology
    2. Evolutionary Biology

    An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

    David S Lorberbaum et al.
    The seemingly simple, constitutive response of the patched/Ptch1 gene to Hedgehog signaling is in fact regulated by large batteries of context-specific Hedgehog-responsive enhancers in both fly and mouse, allowing tissue-specific tuning of the Hedgehog pathway in animal development and evolution.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun et al.
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Structural Biology and Molecular Biophysics

    Beam-induced motion correction for sub-megadalton cryo-EM particles

    Sjors HW Scheres
    Building on previous work (Bai et al., 2013), we describe an algorithm that allows cryo-EM structure determination to near-atomic resolution for protein complexes as small as 170 kDa.

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