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A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.

Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.

Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.

A potential link between metabolic changes resulting from exercise and gene expression in the brain has been revealed.

A noisy cell-intrinsic timer provides positional information for the segmentation clock, modulated by extrinsic factors such as FGF.

A multidisciplinary approach sheds light on the fundamental mechanisms underlying social belief communication under uncertainty.

A novel multi-omics framework revealed the taxonomic contribution to microbiota oxalate, demontrated O. formigenes as the dominating taxon transcriptionally, and identified specific IBD cohort at risk for oxalte toxicity.

Native state dynamics of mouse prion protein were measured, and these motions were shown to be having a role in initiation of aggregation.

A combination of surveillance data, paired sera and mathematical modelling reveals which factors may influence dengue transmission and control in island settings.

Autoinhibition by long-range intramolecular interactions in the partially disordered dynein intermediate chain is relieved by multivalent interactions of dynein light chains, demonstrating for the first time the dual roles of light chains in dynein assembly and regulation.