Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.
Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.
Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
CA1 and PFC bridge the temporal gap between cue and reward delivery during trace conditioning according to different underlying coding principles and task-related activity is reactivated during awake Sharp-Wave Ripples.
Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.
Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
Single-molecule fluorescence experiments reveal transcription initiation proceeds via a 'bind-unwind-load-and-lock' mechanism where promoter DNA unwinds outside the RNA polymerase (RNAP) cleft, the unwound template-DNA loads into the cleft, and RNAP 'locks' the template-DNA by closing the RNAP clamp module.
Data exploring host and parasite signatures in the peripheral blood indicate that total parasite biomass is a better predictor of P. vivax-induced host responses and pathogenesis than peripheral parasitemia.