The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).

Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.

anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.

Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.

Unlike other taste modalities, the Drosophila taste system encodes salt taste combinatorially across multiple sensory neuron classes, which combine to produce behavioural valence and plasticity.

Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.

The identification of evolutionarily-derived changes in Hypocretin function within the brains of short-sleeping Mexican cavefish provides a system for investigating the mechanistic basis of sleep differences throughout the animal kingdom.

The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.

High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.

Optogenetic approaches in young and aged rats define multiple roles for basolateral amygdala in guiding intertemporal choice, and show that these roles change across the lifespan.