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A computer-assisted revision of a unique fossil from Kenya supports the hypothesis that the modern features of our brain emerged recently in the human evolutionary history.

Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.

Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.

In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.

A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.

Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.

Three months treatment with the drug rapamycin increases lifespan, alters cancer prevalence, remodels the microbiome, and improves functional measures of health in middle aged mice in a dose- and sex-dependent manner.

Unlike other taste modalities, the Drosophila taste system encodes salt taste combinatorially across multiple sensory neuron classes, which combine to produce behavioural valence and plasticity.

Activation of adiponectin receptors in young and aged mice induces changes in muscular metabolism via stimulation of AMPK and PGC-1a and ameliorates age-related muscle loss of function.

The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).