An intracellular cytokine receptor 'switch' motif is critical for the dimerization of JAK2 and activation of the JAK2 kinase.

Mutational inactivation of the JNK signaling pathway causes genomic instability and breast cancer development.

Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.

The sampling of visual space is not only warped by attention towards locations but also depends on attended features.

Genomic gains in ovarian cancer can promote cisplatin resistance via a FAK, Wnt/beta-catenin and Myc signaling pathway supporting pluripotency genes and tumorspheres that can acquire FAK dependence for survival.

Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.

Muscarinic excitation of a previously ignored subtype of periglomerular interneuron in the olfactory bulb by endogenous synaptic release of acetylcholine.

Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.

The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.

NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.