3,977 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Neuroscience

    The Digital Brain Bank, an open access platform for post-mortem imaging datasets

    Benjamin C Tendler, Taylor Hanayik ... Karla L Miller
    The Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank) provides curated post-mortem imaging datasets for neuroanatomy, neuropathology, and comparative neuroanatomy investigations, with the first release containing 21 distinctive whole-brain diffusion MRI datasets, alongside microscopy and complementary MRI modalities.
    1. Ecology
    2. Evolutionary Biology

    Megafaunal extinctions, not climate change, may explain Holocene genetic diversity declines in Numenius shorebirds

    Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt
    Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Identifying metabolic features of colorectal cancer liability using Mendelian randomization

    Caroline Bull, Emma Hazelwood ... Emma E Vincent
    Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.
    1. Neuroscience

    Common cell type nomenclature for the mammalian brain

    Jeremy A Miller, Nathan W Gouwens ... Amy Bernard
    A new nomenclature convention for mammalian cell types utilizing shared taxonomies and quantitative cell features is applied to high-quality, open data from the mouse and human brain.
    1. Physics of Living Systems
    2. Stem Cells and Regenerative Medicine

    DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

    Simona Hankeova, Jakub Salplachta ... Emma Rachel Andersson
    Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
    1. Neuroscience

    Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

    Katharina Eichler, Stefanie Hampel ... Andrew M Seeds
    A synaptic resolution somatotopic map of nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations and collectively elicit a head grooming sequence.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    Alex W Chan, Malgorzata Broncel ... Sebastian Lourido
    Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
    1. Evolutionary Biology

    Muscle systems and motility of early animals highlighted by cnidarians from the basal Cambrian

    Xing Wang, Jean Vannier ... Jian Han
    Exceptionally preserved small shelly fossils (SSFs) from the early Cambrian Kuanchuanpu Formation (535 million years ago) reveal the muscular system of ancient cnidarians.

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