31 results found
    1. Computational and Systems Biology

    Cutting Edge: Anatomy of BioJS, an open source community for the life sciences

    Guy Yachdav et al.
    Community nurturing is the single most important factor in determining the sustainability of an open source project such as BioJS.
    1. Human Biology and Medicine

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression

    Yuan Xue et al.
    Single-cell RNA-sequencing resolves the transcriptional landscape of asexual development in Toxoplasma gondii, revealing concerted genetic programs to Plasmodiumfalciparum and a novel transcriptional factor that controls antigen switching.
    1. Neuroscience

    Value generalization in human avoidance learning

    Agnes Norbury et al.
    Individual differences in generalization of aversive value (but not safety information) during human active avoidance learning specifically predict experience of anxiety and intrusive thoughts.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Population genomics of intrapatient HIV-1 evolution

    Fabio Zanini et al.
    Whole genome deep sequencing of many longitudinally sampled HIV-1 populations reveals that reversions towards ancestral HIV-1 genome sequences occur throughout the course of infection.
    1. Neuroscience

    SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters

    Jeremy Magland et al.
    Ten popular spike sorting codes are reproducibly benchmarked for accuracy on electrophysiology datasets from eleven laboratories with interactive web-based exploration of thousands of ground-truth units.
    1. Microbiology and Infectious Disease

    Single-cell transcriptional dynamics of flavivirus infection

    Fabio Zanini et al.
    A novel virus-inclusive single cell RNA-Seq approach enables identification of novel pro- and antiviral host factors in human cells in response to dengue and Zika virus infection.
    1. Neuroscience

    DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila

    Semih Günel et al.
    DeepFly3D, a deep learning-based software, measures limb and appendage movements in tethered, behaving Drosophila and enables precise behavioral measurements during neural recordings, stimulation, and other biological experiments.
    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding et al.
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.

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