Mutations in KIAA0586 (TALPID3) cause a severe ciliopathy called Joubert syndrome that affects organ, cell and centrosome polarity.

A supervised learning approach on a high-content genome-wide siRNA screen has identified 591 likely candidates for ciliopathies and facilitated in the discovery of KIAA0586 mutations in individuals with Joubert syndrome.

The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.

Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.

Telomere length distributions can be used to infer important properties of stem cell proliferation.

Wss1 is both a metalloprotease and SUMO ligase found in association with Cdc48 and Doa1 and accumulating in the vacuole upon DNA damage.

A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.

Neural activity in the rat nucleus accumbens provides a rich task representation that includes not only expected outcomes, but also the specific identity of the cues that predict these outcomes.

Thalidomide and its derivates induce degradation of many C₂H₂ zinc-finger transcription factors, including SALL4, providing insight into a long-standing mystery in modern pharmacology, and starting points for future drug development.