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    1. Computational and Systems Biology

    Focal seizures are organized by feedback between neural activity and ion concentration changes

    Damiano Gentiletti, Marco de Curtis ... Piotr Suffczynski
    Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne, Jean-Patrick Vrel, Pierre Sens
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

    Olivier Cochet-Escartin, Mete Demircigil ... Jean-Paul Rieu
    Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
    1. Neuroscience

    AVN: A Deep Learning Approach for the Analysis of Birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Accelerated signal propagation speed in human neocortical dendrites

    Gáspár Oláh, Rajmund Lákovics ... Gábor Tamás
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Ecology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of nested Darwinian populations and the emergence of community-level heredity

    Guilhem Doulcier, Amaury Lambert ... Paul B Rainey
    Artificial selection on communities drives the evolution of interactions and establishes community-level inheritance.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Neuroscience

    Shortcutting from self-motion signals reveals a cognitive map in mice

    Jiayun Xu, Mauricio Girardi-Schappo ... Leonard Maler
    Mice can use self-motion cues to learn a cognitive map thereby permitting them to take shortcut trajectories in an open maze without requiring prior experience of such routes.