5,287 results found
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

    Anirban Banerjee et al.
    Charybdotoxin, a toxin produced by scorpions, blocks a K+ channel by binding in a lock-and-key fashion to the mouth of the channel and presenting a lysine amino group, which serves as a K+ mimic in the selectivity filter.
    1. Medicine

    Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

    Hua-Qian Yang et al.
    The functional interaction of Na+ and KATP channels at the intercalated disk of cardiomyocytes depends on Ankyrin G and is clinically relevant since KATP channel mutations affect Na+ channel expression.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the human Slo1 K+ channel in complex with β4

    Xiao Tao, Roderick MacKinnon
    The structures of Slo1 in complex with b4 imply that the auxiliary beta subunits modulate the channel's gating properties through stabilizing ‘pre-existing’ conformations rather than creating new ones.
    1. Structural Biology and Molecular Biophysics

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong et al.
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.
    1. Structural Biology and Molecular Biophysics

    Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

    SeCheol Oh et al.
    Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of K+ ions.
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin et al.
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Structural Biology and Molecular Biophysics

    The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

    Susanne Rinné et al.
    A combined systematic alanine scanning and molecular modelling approach reveals the molecular basis for an allosteric inhibition mechanism of K+-flux gating in K2P channels.
    1. Neuroscience

    BAD and KATP channels regulate neuron excitability and epileptiform activity

    Juan Ramón Martínez-François et al.
    Altered activity of ATP-sensitive K+ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.
    1. Structural Biology and Molecular Biophysics

    Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

    Samuel G Usher et al.
    Simultaneous measurements of ligand binding and channel currents are used to understand gating of the ATP-sensitive K+ channel.
    1. Neuroscience

    Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons

    Koun Onodera et al.
    Drosophila nociceptive neurons convert high-intensity stimuli into characteristic fluctuations of firing rates, quiescent periods of which are regulated by hyperpolarization through small conductance Ca2+-activated K+ channels.

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