Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.

Clear guidelines and open-source software resources are provided for the stop-signal task, in order to streamline the use of this important tool, and to thereby increase its validity and reliability.

The switch from ubiquinone to rhodoquinone synthesis that is required for parasitic helminths to survive in anaerobic host tissues is due to alternative splicing of polyprenyltransferase COQ-2.

Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.

The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.

A new hominin species has been unearthed in the Dinaledi Chamber of the Rising Star cave system in the largest assemblage of a single species of hominins yet discovered in Africa.

The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.

Genetically diverse rats reveal a single underlying construct linking key addiction-like behaviors, challenging compulsivity as an independent measure, and offering a new perspective on vulnerability and resilience to addiction.

During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.

Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.