12,279 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh, William H Barnett ... Ronald L Calabrese
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Structural Biology and Molecular Biophysics

    Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

    Samuel G Usher, Frances M Ashcroft, Michael C Puljung
    Simultaneous measurements of ligand binding and channel currents are used to understand gating of the ATP-sensitive K+ channel.
    1. Structural Biology and Molecular Biophysics

    Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

    Michael Puljung, Natascia Vedovato ... Frances Ashcroft
    A combined FRET- and electrophysiology-based approach is used to study ATP/ADP ADP binding to the stimulatory nucleotide binding site of ATP-sensitive K+ channels and investigate their activation mechanism.
    1. Cell Biology
    2. Developmental Biology

    Cancer: Evolution, ovulation and cancer

    K VijayRaghavan, Satyajit Rath
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Eric Deneault, Muhammad Faheem ... Stephen W Scherer
    Autism-associated iPSC-derived neurons mutant in CNTN5 or EHMT2 are hyperactive.
    1. Microbiology and Infectious Disease

    The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria

    Sara C Di Rienzi, Itai Sharon ... Ruth E Ley
    Melainabacteria, a candidate phylum related to Cyanobacteria, has been identified in gut and sediment samples by genomic analysis.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

    Anirban Banerjee, Alice Lee ... Roderick MacKinnon
    Charybdotoxin, a toxin produced by scorpions, blocks a K+ channel by binding in a lock-and-key fashion to the mouth of the channel and presenting a lysine amino group, which serves as a K+ mimic in the selectivity filter.
    1. Cell Biology
    2. Physics of Living Systems

    Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

    Manuela Richter, Lila Neahring ... Sophie Dumont
    Live imaging and physical perturbations of spindles with unfocused poles reveal that mammalian spindle length emerges locally from kinetochore-fibers, but that global cues from focused spindle poles are needed to coordinate k-fibers across space and time and accurately segregate chromosomes.
  1. Point of View: Basic research at the epicenter of an epidemic

    William R Bishai
    William R Bishai, director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), argues that the best place to carry out research into a disease is in its midst.
    1. Microbiology and Infectious Disease

    Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

    Michaela Gregorova, Daniel Morse ... Ruth C Massey
    Post-acute or long-COVID is associated with bystander T-cell activation and a recurring antimicrobial resistant, bacterial ventilator-associated pneumonia.

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