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The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.

High-resolution structures of HIV-1 RT in complex with two newly developed non-nucleoside inhibitors explain how they retain antiviral activities against drug-resistant RT mutants with considerably reduced susceptibility to rilpivirine.

Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of K+ ions.

The structures of Slo1 in complex with b4 imply that the auxiliary beta subunits modulate the channel's gating properties through stabilizing ‘pre-existing’ conformations rather than creating new ones.

Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (K_ATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.

Lysine mono- and di-methylation are two novel post-translational modifications of RNA polymerase II, which are enriched at promoters of active genes, precede lysine acetylation and mark early stages of transcription.

A striking and consequential conductance in vestibular type I hair cells is finally shown to depend on a little-known Shaker subunit that contributes to conventional conductances in other hair cells.

Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.

A novel technology for recording muscle activity provides unprecedented access to the electrical signals that control the body across muscles, species, and behaviors.

Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.