1,205 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genetic analysis reveals functions of atypical polyubiquitin chains

    Fernando Meza Gutierrez et al.
    A comprehensive genetic interaction screen uncovered biological roles of K11 linkages in amino acid homeostasis and cell cycle regulation in yeast.
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo et al.
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Sex-specific triacylglycerides are widely conserved in Drosophila and mediate mating behavior

    Jacqueline SR Chin et al.
    Triacylglycerides found in the males of 11 species of Drosophila form a largely overlooked, novel, sex-specific class of pheromones that act to suppress courtship behaviour.
    1. Neuroscience

    A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

    Yangyu Wu et al.
    Three residues work together as a valve-like mechanism to control desensitization from pre-open and open states in the ion channels ASIC1a, ASIC2a, and ASIC3.
    1. Plant Biology
    2. Genetics and Genomics

    The Natural History of Model Organisms: Genetic, evolutionary and plant breeding insights from the domestication of maize

    Sarah Hake, Jeffrey Ross-Ibarra
    Comparing maize to its wild ancestor teosinte advances our understanding of how it and other cereal crops evolved, and also identifies the genetic variation that can contribute to important agricultural traits.
    1. Ecology
    2. Evolutionary Biology

    Evolutionary Morphology: One size does not fit all

    Diethard Tautz
    Insight
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    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
  1. Research Culture: A survey of new PIs in the UK

    Sophie E Acton et al.
    The challenges faced by new PIs in the UK include difficulties in recruiting PhD students, maintaining a good work-life balance and securing permanent positions.
  2. Meta-Research: Tracking the popularity and outcomes of all bioRxiv preprints

    Richard J Abdill, Ran Blekhman
    Data are reported for the monthly number of uploads to and downloads from bioRxiv, and for the number of preprints that are later published in peer-reviewed journals.

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