1,146 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genetic analysis reveals functions of atypical polyubiquitin chains

    Fernando Meza Gutierrez et al.
    A comprehensive genetic interaction screen uncovered biological roles of K11 linkages in amino acid homeostasis and cell cycle regulation in yeast.
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo et al.
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Neuroscience

    Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

    Sandra Kleinecke et al.
    Dysfunctions of myelin peroxisomes cause a lysosomal storage-like disorder associated with alterations in glial and axonal membranes, which is the likely cause of nerve impairment in peroxisomal disorders.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Sex-specific triacylglycerides are widely conserved in Drosophila and mediate mating behavior

    Jacqueline SR Chin et al.
    Triacylglycerides found in the males of 11 species of Drosophila form a largely overlooked, novel, sex-specific class of pheromones that act to suppress courtship behaviour.
    1. Neuroscience

    A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

    Yangyu Wu et al.
    Three residues work together as a valve-like mechanism to control desensitization from pre-open and open states in the ion channels ASIC1a, ASIC2a, and ASIC3.
    1. Plant Biology
    2. Genetics and Genomics

    The Natural History of Model Organisms: Genetic, evolutionary and plant breeding insights from the domestication of maize

    Sarah Hake, Jeffrey Ross-Ibarra
    Comparing maize to its wild ancestor teosinte advances our understanding of how it and other cereal crops evolved, and also identifies the genetic variation that can contribute to important agricultural traits.
    1. Ecology
    2. Evolutionary Biology

    Evolutionary Morphology: One size does not fit all

    Diethard Tautz
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    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Stem Cells and Regenerative Medicine

    Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

    Bo Shen et al.
    Integrin a11 is identified as an Osteolectin receptor, revealing a new mechanism for adult skeletal bone maintenance in which Osteolectin/a11b1 signaling promotes bone formation by activating the Wnt pathway.

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