1,814 results found
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee et al.
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Identification of cryptic subunits from an apicomplexan ATP synthase

    Diego Huet et al.
    A phylum-specific ATP synthase subunit is needed for proper mitochondrial function and stability of the complex in Toxoplasma gondii.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a bacterial ATP synthase

    Hui Guo et al.
    Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.
    1. Cell Biology

    Mitochondrial flashes regulate ATP homeostasis in the heart

    Xianhua Wang et al.
    Mitochondrial flashes counteract the imbalance of ATP supply-and-demand and constitute an auto-regulator of ATP homeostasis in the heart.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

    Daniel Elnatan et al.
    A flip of the dimer asymmetry following the first ATP hydrolysis provides a mechanistic model for client remodeling by the mitochondrial Hsp90, TRAP1.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

    Gregory M Martin et al.
    Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (KATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

    Nicholas Mikolajewicz et al.
    Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.
    1. Cell Biology
    2. Developmental Biology

    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli

    Michael H Hayes et al.
    The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

    Meghna Sobti et al.
    A molecular model that provides a framework for interpreting the wealth of functional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron microscopy.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

    Blake R Wilde et al.
    The MondoA transcription factor localizes to the outer mitochondrial membrane where it coordinates an adaptive transcriptional response to elevated cellular energy represented by high cytoplasmic glucose and high mitochondrial ATP.

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