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Microbiology and Infectious Disease
Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1
Sean R Cuddy et al.
Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
chTOG is a conserved mitotic error correction factor
Jacob A Herman et al.
The conserved chTOG protein is required to destabilize incorrect kinetochore-microtubule attachments.
Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
Jin Rong Ow et al.
Loss of hepatic
leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
Chromosomes and Gene Expression
Computational and Systems Biology
Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals
Eric M Sanford et al.
When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
Regulation of shoot meristem shape by photoperiodic signaling and phytohormones during floral induction of Arabidopsis
Atsuko Kinoshita et al.
The shoot meristem becomes domed in shape during floral transition and this is controlled by flowering pathways and the phytohormone gibberellin causing increases in cell size and number.
Stem Cells and Regenerative Medicine
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells
Diana Gumber et al.
Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming
Hong Wang et al.
A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.
Immunology and Inflammation
Structural Biology and Molecular Biophysics
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops
Christopher T Boughter et al.
A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.
Genetics and Genomics
Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks
Beryl M Jones et al.
Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons
Bastien Saint-Leandre et al.
Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in
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