Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
The shoot meristem becomes domed in shape during floral transition and this is controlled by flowering pathways and the phytohormone gibberellin causing increases in cell size and number.
Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.
Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
