19 results found
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

    Hayden AM Hatch et al.
    The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.
    1. Genetics and Genomics
    2. Medicine

    KDM5A mutations identified in autism spectrum disorder using forward genetics

    Lauretta El Hayek et al.
    Successful autism spectrum disorder gene discovery using forward genetics identifies KDM5A, which encodes a histone H3 lysine 4 demethylase, as a disease gene.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

    Lili Liao et al.
    Major secondary tumor suppressors in kidney cancer are required to maintain the activity of a tumor suppressive transcription factor after the loss of the primary tumor suppressor VHL.
    1. Developmental Biology

    Regulation of X-linked gene expression during early mouse development by Rlim

    Feng Wang et al.
    Single embryo RNA-seq combined with mouse genetics provides a comprehensive view on the roles of Rlim and Xist for the regulation of X-linked gene expression during early mouse embryogenesis.
    1. Developmental Biology

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

    Ruben Soto-Acosta et al.
    The Zika virus subgenomic flaviviral RNA binds to and inhibits the fragile X mental retardation protein, a novel Zika virus restriction factor.
    1. Neuroscience

    Astrocytes release prostaglandin E2 to modify respiratory network activity

    David Forsberg et al.
    Astrocytes modulate neuronal networks during hypercapnia, introducing a novel gliotransmitter pathway where prostaglandin E2 regulates breathing.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi et al.
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.

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