150 results found
    1. Structural Biology and Molecular Biophysics

    Mechanism of activation at the selectivity filter of the KcsA K+ channel

    Florian T Heer et al.
    The transmembrane helices forming the pore determine the conductance of the selectivity filter through allosteric interactions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The gating cycle of a K+ channel at atomic resolution

    Luis G Cuello et al.
    X-ray crystallographic studies have completed the first atomic resolution description of the kinetic cycle of a potassium channel's pore domain.
    1. Neuroscience

    Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

    Yanying Wu et al.
    Regulated neuronal magnesium efflux is a critical element of normal and magnesium-enhanced memory.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

    Yun Pyo Kang et al.
    By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao et al.
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
    1. Neuroscience

    A connectome of a learning and memory center in the adult Drosophila brain

    Shin-ya Takemura et al.
    Connectomic analysis in the fly's (Drosophila) learning and memory center identifies unique circuit motifs that have not been anticipated by over 30 years of extensive anatomical, experimental and theoretical studies.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Neuroscience

    Direct neural pathways convey distinct visual information to Drosophila mushroom bodies

    Katrin Vogt et al.
    Building on previous work (Vogt et al. 2014), separate visual pathways have been identified to convey information for brightness and color to the learning-related area of the Drosophila brain.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

    Cedric Leyrat et al.
    A combination of X-ray crystallography, molecular dynamics and small angle X-ray scattering shows that the transcription antiterminator M2-1 is a structurally dynamic homotetramer that undergoes large concerted conformational changes upon binding its target RNA.
    1. Neuroscience

    Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila

    Qingqing Liu et al.
    Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.

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