316 results found
    1. Developmental Biology

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe et al.
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

    Graeme Gossel et al.
    The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

    Jinrui Dong et al.
    IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.
    1. Cell Biology

    The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

    Tsung-Chieh Lin et al.
    NIFK promotes lung cancer metastasis via Runx1-dependent repression of CK1α, which activates TCF4/β-catenin signaling.
    1. Immunology and Inflammation

    Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

    Amijai Saragovi et al.
    Systemic hypoxia model reveals the detrimental effect of hypoxia on mitochondrial biogenesis in activated T-cells and points at a new approach for improving viral resistance in patients with respiratory diseases.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations

    Leah Bury et al.
    Single molecule FISH analysis defines the behavior of centromere-derived alpha-satellite transcripts in intact human cells and reveals a critical role for centromere-nucleolar contacts in repressing alpha-satellite transcription.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi et al.
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal et al.
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
    1. Developmental Biology

    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

    Fatih Semerci et al.
    In adult mouse hippocampus, neural stem cell and their progeny communicate via Lunatic Fringe mediated Notch signaling to regulate stem cell quiescence, division, and fate.

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