57 results found
    1. Neuroscience

    Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses

    Anita V Devineni et al.
    A single taste input, acetic acid, elicits opposing behavioral outputs depending on a fly's hunger state.
    1. Neuroscience

    Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

    Shun-Fan Wu et al.
    Drosophila use distinct sensory mechanisms to detect and integrate the same tactile and taste information in two decision-making tasks that serve two different purposes.
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz et al.
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Neuroscience

    A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

    Nan Jiang et al.
    Epidermal cells in vertebrates and invertebrates ensheath portions of somatosensory neurons via a conserved morphogenetic mechanism, and this ensheathment regulates morphogenesis and function of Drosophila nociceptive neurons.
    1. Neuroscience

    Neurocalcin regulates nighttime sleep and arousal in Drosophila

    Ko-Fan Chen et al.
    The neuronal calcium sensor Neurocalcin regulates sleep and arousal thresholds during the night in Drosophila.
    1. Structural Biology and Molecular Biophysics

    Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

    Michael Puljung et al.
    A combined FRET- and electrophysiology-based approach is used to study ATP/ADP ADP binding to the stimulatory nucleotide binding site of ATP-sensitive K+ channels and investigate their activation mechanism.
    1. Developmental Biology
    2. Neuroscience

    Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

    Luis F Sullivan et al.
    The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
    1. Neuroscience

    Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs

    Jinfei D Ni et al.
    Functional imaging and circuit mapping in the Drosophila brain identifies neuropils where sleep-promoting and arousal-promoting neuronal networks converge.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of signaling specificity between GIRK channels and GPCRs

    Kouki K Touhara, Roderick MacKinnon
    A single kinetic step in the G protein activation cycle determines whether a G protein-coupled receptor activates G protein-gated K+ channels or not.

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