An experimental and computational system has been developed to investigate how wavelike gene expression patterns are generated during embryonic development.
James W Truman, Lynn M Riddiford ... Michelle Herko
This sesquiterpene hormone likely acted as a morphogenesis-to-differentiation switch in archaic embryos before it evolved its postembryonic function as the status quo regulator of insect metamorphosis.
A combination of unbiased scRNA-sequencing and functional approaches in organoid cultures and injury-repair models in vivo reveals major heterogeneity in adult murine airway basal cells, which is established prenatally and conserved in humans.