73 results found
    1. Cell Biology

    KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

    Anthony A Ruberto, Aline Gréchez-Cassiau ... Michèle Teboul
    Krüppel-like factor 10 coordinates the hepatic circadian transcriptome and protects the liver from the adverse effects of increased sugar consumption.
    1. Developmental Biology

    Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice

    Shinichiro Hayashi, Ichiro Manabe ... Yumiko Oishi
    The regulatory programs governing skeletal muscle regeneration that are controlled by Klf5 in cooperation with MyoD and Mef2 provide a potential avenue for intervention into muscle regeneration through modulation of Klf5.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan, Yijing Su ... Shuli Xia
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    1. Developmental Biology

    EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis

    Kaustav Mukherjee, Li Xue ... James J Bieker
    Mouse fetal liver macrophages that support erythroid differentiation within erythroblastic islands exhibit a unique and transient expression signature under transcriptional control of EKLF/KLF1.
    1. Developmental Biology

    Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

    Shiri Kult, Tsviya Olender ... Elazar Zelzer
    The molecular identity of bi-fated tendon-to-bone attachment cells, which display a mixture of transcriptomes of two neighboring cell types, enables the formation of the unique transitional tissue of the enthesis.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim, Yue-He Ding ... Craig C Mello
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Chromosomes and Gene Expression

    EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

    Ananya Pal, Jia Yu Leung ... Reshma Taneja
    Inhibition of the lysine methyltransferase G9a blocks oncogenic phenotypes in embryonal rhabdomyosarcoma.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu, Yiyun Wang ... Aaron W James
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé, Ezzat El-Sherif, Paul François
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.
    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill, Tyler J Gibson ... Melissa M Harrison
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.

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