Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.

Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.

Interactions between Hox and TALE genes, which generate bilaterally symmetrical body plans, originated in early multicellular animals.

Two complexes that contain the histone acetyl transferase MOF engage in a two-pronged approach to ensure the repression of X inactivation in mouse embryonic stem cells.

A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.

Dali regulates transcription of the Pou3f3 locus locally and binds and regulates active promoters in trans by modulating DNA methylation status.

In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.

Direct measurements of retinoic acid using fluorescence lifetime imaging reveal a new role for cellular retinoic acid binding proteins in noise attenuation that is critical to sharpen hindbrain rhombomere boundaries.

The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.

The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.